Author Topic: ASTHMA  (Read 1095 times)

Emmerson Elliot

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ASTHMA
« on: August 24, 2015, 12:37:52 AM »
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Ryan Ryder

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Asthma and airways collapse in two heritable disorders of connective tissue
« Reply #1 on: December 27, 2015, 12:41:37 AM »
Asthma and airways collapse in two heritable disorders of connective tissue

Ann Rheum Dis. 2007 Oct; 66(10): 1369–1373.
Published online 2007 Apr 5. doi:  10.1136/ard.2006.062224
PMCID: PMC1994284
Asthma and airways collapse in two heritable disorders of connective tissue
A W Morgan, S B Pearson, S Davies, H C Gooi, and H A Bird

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994284/

RR


« Last Edit: December 27, 2015, 12:56:05 AM by Ryan Ryder »

Ryan Ryder

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Re: ASTHMA
« Reply #2 on: December 27, 2015, 12:42:58 AM »
ISRN Dermatology
Volume 2012 (2012), Article ID 751768, 22 pages
http://dx.doi.org/10.5402/2012/751768
Review Article
Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations
Marco Castori

Morgan et al. found an increased rate of asthmatic symptoms and atopy associated with increased lung volumes, impaired gas exchange, and an increased tendency of both the lower and upper airways to collapse in JHS/EDS-HT [125]. Soyucen and Esen postulated that JHS/EDS-HT may predispose to asthma [126]. In fact, JHS/EDS-HT may lead to persistent childhood wheezing by causing airway collapse through a connective tissue defect affecting airways structure [126]. Further studies are needed to confirm this hypothesis.

http://www.hindawi.com/journals/isrn/2012/751768/

RR

Ryan Ryder

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Re: ASTHMA
« Reply #3 on: December 27, 2015, 12:49:42 AM »
****Not about asthma directly but related to breathing...excellent article though.*****

EDS & Sleep Disordered Breathing:

Note:  Full article available & attached

Sleep-Disordered Breathing in Ehlers-Danlos Syndrome: A Genetic Model of OSA

Abstract

Objectives:  The objective of this study was to investigate the presence of sleep-disordered breathing (SDB) in patients with Ehlers-Danlos syndrome. Ehlers-Danlos syndrome is a genetic disorder characterized by cartilaginous defects, including nasal-maxillary cartilages.

Conclusions: 

...These patients are at particular risk for SDB because of genetically related cartilage defects that lead to the development of facial structures known to cause SDB.

Ehlers-Danlos syndrome may be a genetic model for OSA because of abnormalities in oral-facial growth. Early recognition of SDB may allow treatment with orthodontics and myofacial reeducation.

...The craniofacial complex involves the maxilla and mandible. The size of these components likely is the element that is most influenced by genetics, which is important because size influences shape.10

For example, a change in the length of the mandibular body alters the shape of the face. Changing only one dimension can alter how the other parts fit together.

The direction in which growth occurs is influenced by the surrounding hard and soft tissues. Genes involved in the development of one tissue (eg, cartilage) will have a secondary epigenetic effect on another tissue.10

http://journal.publications.chestnet.org/Mobile/article.aspx?articleid=1725193


Full Article PDF:

https://www.researchgate.net/profile/Hsiao_Yean_Chiu/publication/255715805_Sleep-Disordered_Breathing_in_Ehlers-Danlos_Syndrome_A_Genetic_Model_of_OSA/links/542dfa810cf27e39fa95fc8e/Sleep-Disordered-Breathing-in-Ehlers-Danlos-Syndrome-A-Genetic-Model-of-OSA.pdf 


RR
« Last Edit: January 31, 2017, 10:26:44 PM by Ryan Ryder »